বুধবার, ২ জানুয়ারী, ২০১৩

PET/CT shows clear advantages over conventional staging for breast cancer patients

PET/CT shows clear advantages over conventional staging for breast cancer patients [ Back to EurekAlert! ] Public release date: 2-Jan-2013
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Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine

Reston, Va. (January 2, 2013) New research published in the January issue of The Journal of Nuclear Medicine shows that 18F-fludeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging offers significant prognostic stratification information at initial staging for patients with locally advanced breast cancer. When compared to conventional imaging, 18F-FDG PET/CT more accurately showed lesions in the chest, abdomen and bones in a single session, changing management for more than 50 percent of the patients in the study.

Guidelines from the National Comprehensive Cancer Network (NCCN) recommend a physical examination, bilateral mammogram, sonography or breast magnetic resonance (MR) imaging to examine the breast, as well as chest diagnostic CT, abdominal or pelvic diagnostic CT or MR imaging and bone scanning for evaluation of distant involvement. The NCCN guidelines consider 18F-FDG PET/CT to be "most helpful in situations where standard staging studies are equivocal or suspicious."

"The prognosis of patients with locally advanced breast cancer remains poor. In this study we aimed to investigate whether the use of 18F-FDG PET/CT at initial staging could have an impact on the prognostic stratification and management of patients with locally advanced breast cancer," said David Groheux, MD, PhD, lead author of the study "18F-FDG PET/CT in Staging Patients with Locally Advanced or Inflammatory Breast Cancer: Comparison to Conventional Staging."

One hundred and seventeen patients with locally advanced breast cancer were prospectively included in the study over a course of five years. Patients underwent conventional imaging methods, including bone scanning, chest radiography, or dedicated CT and abdominopelvic examination by sonography or contrast-enhanced CT and were staged accordingly. They then received an 18F-FDG PET/CT scan, which was reviewed by nuclear medicine specialists with no knowledge of the conventional imaging results. The conventional imaging and 18F-FDG imaging results were then compared.

All primary tumors were identified by 18F-FDG PET/CT. The scans confirmed lymph node involvement in stage IIIC patients and revealed unsuspected lymph node involvement in 32 additional patients. Furthermore, distant metastases (bone, distant lymph nodes, liver, lung and pleura) were visualized with 18F-FDG PET/CT in 43 patients; conventional imaging only identified 28 patients with distant metastases. Overall, 18F-FDG PET/CT changed the stage of 61 out of 117 patients, which, in turn, impacted the recommended treatment for the patients.

"This is a step toward the truly personalized medicine that molecular imaging can bringacquiring an image that provides sufficient information to truly tailor management strategies to the singular needs of each patient," noted Groheux. "Based on these findings, 18F-FDG PET/CT may become the single most important distant staging modality in patients with locally advanced breast cancer."

###

Authors of the article "18F-FDG PET/CT in Staging Patients with Locally Advanced or Inflammatory Breast Cancer: Comparison to Conventional Staging" include David Groheux, Department of Nuclear Medicine, Saint-Louis Hospital, Paris, France, and B2T, Doctoral School, IUH, University of Paris VII, France; Laetitia Vercellino and Marie-Elisabeth Toubert, Department of Nuclear Medicine, Saint-Louis Hospital, Paris, France; Pascal Merlet, Department of Nuclear Medicine, Saint-Louis Hospital, Paris, France, and Service Hospitalier Frederic Joliot, SHFJ/I2BM/DSVCEA, Orsay, France; Elif Hindie, B2T, Doctoral School, IUH, University of Paris VII, France, and Department of Nuclear Medicine, Haut-Leveque Hospital, CHU Bordeaux, University of Bordeaux-Segalen, Bordeaux, France; Sylvie Giacchetti, Caroline Cuvier and Marc Espie, Breast Diseases Unit, Department of Medical Oncology, Saint-Louis Hospital, Paris, France; Marc Delord, Department of Biostatistics and Bioinformatics, Institut Universitaire d'Hematologie, Paris, France; and Christophe Hennequin, Department of Radiation Oncology, Saint-Louis Hospital, Paris, France.


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PET/CT shows clear advantages over conventional staging for breast cancer patients [ Back to EurekAlert! ] Public release date: 2-Jan-2013
[ | E-mail | Share Share ]

Contact: Susan Martonik
smartonik@snmmi.org
703-652-6773
Society of Nuclear Medicine

Reston, Va. (January 2, 2013) New research published in the January issue of The Journal of Nuclear Medicine shows that 18F-fludeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging offers significant prognostic stratification information at initial staging for patients with locally advanced breast cancer. When compared to conventional imaging, 18F-FDG PET/CT more accurately showed lesions in the chest, abdomen and bones in a single session, changing management for more than 50 percent of the patients in the study.

Guidelines from the National Comprehensive Cancer Network (NCCN) recommend a physical examination, bilateral mammogram, sonography or breast magnetic resonance (MR) imaging to examine the breast, as well as chest diagnostic CT, abdominal or pelvic diagnostic CT or MR imaging and bone scanning for evaluation of distant involvement. The NCCN guidelines consider 18F-FDG PET/CT to be "most helpful in situations where standard staging studies are equivocal or suspicious."

"The prognosis of patients with locally advanced breast cancer remains poor. In this study we aimed to investigate whether the use of 18F-FDG PET/CT at initial staging could have an impact on the prognostic stratification and management of patients with locally advanced breast cancer," said David Groheux, MD, PhD, lead author of the study "18F-FDG PET/CT in Staging Patients with Locally Advanced or Inflammatory Breast Cancer: Comparison to Conventional Staging."

One hundred and seventeen patients with locally advanced breast cancer were prospectively included in the study over a course of five years. Patients underwent conventional imaging methods, including bone scanning, chest radiography, or dedicated CT and abdominopelvic examination by sonography or contrast-enhanced CT and were staged accordingly. They then received an 18F-FDG PET/CT scan, which was reviewed by nuclear medicine specialists with no knowledge of the conventional imaging results. The conventional imaging and 18F-FDG imaging results were then compared.

All primary tumors were identified by 18F-FDG PET/CT. The scans confirmed lymph node involvement in stage IIIC patients and revealed unsuspected lymph node involvement in 32 additional patients. Furthermore, distant metastases (bone, distant lymph nodes, liver, lung and pleura) were visualized with 18F-FDG PET/CT in 43 patients; conventional imaging only identified 28 patients with distant metastases. Overall, 18F-FDG PET/CT changed the stage of 61 out of 117 patients, which, in turn, impacted the recommended treatment for the patients.

"This is a step toward the truly personalized medicine that molecular imaging can bringacquiring an image that provides sufficient information to truly tailor management strategies to the singular needs of each patient," noted Groheux. "Based on these findings, 18F-FDG PET/CT may become the single most important distant staging modality in patients with locally advanced breast cancer."

###

Authors of the article "18F-FDG PET/CT in Staging Patients with Locally Advanced or Inflammatory Breast Cancer: Comparison to Conventional Staging" include David Groheux, Department of Nuclear Medicine, Saint-Louis Hospital, Paris, France, and B2T, Doctoral School, IUH, University of Paris VII, France; Laetitia Vercellino and Marie-Elisabeth Toubert, Department of Nuclear Medicine, Saint-Louis Hospital, Paris, France; Pascal Merlet, Department of Nuclear Medicine, Saint-Louis Hospital, Paris, France, and Service Hospitalier Frederic Joliot, SHFJ/I2BM/DSVCEA, Orsay, France; Elif Hindie, B2T, Doctoral School, IUH, University of Paris VII, France, and Department of Nuclear Medicine, Haut-Leveque Hospital, CHU Bordeaux, University of Bordeaux-Segalen, Bordeaux, France; Sylvie Giacchetti, Caroline Cuvier and Marc Espie, Breast Diseases Unit, Department of Medical Oncology, Saint-Louis Hospital, Paris, France; Marc Delord, Department of Biostatistics and Bioinformatics, Institut Universitaire d'Hematologie, Paris, France; and Christophe Hennequin, Department of Radiation Oncology, Saint-Louis Hospital, Paris, France.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-01/sonm-psc010213.php

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মঙ্গলবার, ১ জানুয়ারী, ২০১৩

Chicago's next prosecutor to be more of an insider

CHICAGO (AP) ? The lanky, soft-spoken lawman from New York arrived in Chicago with a mandate to clean up corruption-plagued Illinois. And after a decade on the job, Patrick Fitzgerald had helped put two successive governors and a long procession of other public officials behind bars.

Months after the consummate outsider resigned as head of the U.S. attorney's office in Chicago to enter private practice, the White House is expected to name Fitzgerald's replacement soon from among four finalists ? all of whom are comparative Chicago insiders.

Whoever is picked, the next U.S. attorney will step in to what is widely regarded as Chicago's second-most powerful job, next only to the mayor. The chief prosecutor and around 170 assistant attorneys also have an impact beyond Chicago and Illinois, including by handling major terrorism cases.

"The fantastic thing about Fitzgerald was that he maintained his independence," said Kathleen Zellner, a Chicago-based defense attorney. "I'm not saying these candidates won't be independent, but it's hard to decide to prosecute when you have (such close) connections to a town."

The list of four finalists ? Lori Lightfoot, Zachary Fardon, Jonathan Bunge and Gil Soffer ? was recently forwarded to the Obama administration by Illinois' two U.S. senators, who set-up a screening committee to vet a longer list of prospective candidates over several months.

All four know their way around the federal prosecutor's office in Chicago ? one of the nation's busiest ? each having worked there as assistant attorneys at some point. Fardon, for instance, was a member of Fitzgerald's trial team that convicted former Illinois Gov. George Ryan on corruption charges in 2006.

If Lightfoot is named, she would make history as the first African-American and first woman to head the office.

But what stands out about the four, as a group, is that none could be described as an outsider. All four, who are little known outside legal circles, are currently partners in big-name law offices in Chicago. All have spent at least several years of their legal careers in the city.

At the time of his surprise pick in 2001, Fitzgerald was co-chief of the organized crime and terrorism unit for the U.S. attorney's office in the Southern District of New York. The thinking was that he'd be more willing to go after Illinois politicians because he had no ties to them.

It seemed to work, Zellner said. Ryan, a Republican, and former Gov. Rod Blagojevich, a Democrat, are both in prison on corruption convictions after investigations spearheaded by Fitzgerald. He helped send dozens of other city and state officials to prison.

Appointing someone with Chicago ties may convey confidence that Chicago is no longer as corrupt as it was, said Gal Pissetzky, another Chicago attorney. He said it could signal a desire to shift focus away from corruption and on to other persistent Chicago crime, such as drug trafficking or gang-related murders.

"If you want to tackle these issues, it might make sense to have someone from Chicago," he said. "They know the inner workings of Chicago. And law enforcement will be more cooperative when you bring someone from the inside, from Chicago."

The finalists haven't spoken publicly about their candidacy, or about whether they would change in office priorities.

In a letter to the U.S. senators describing interviews with the four, however, the co-chairs of the screen committee wrote that, "All share the belief ? though with slightly differing ordering ? that the primary subject matter concerns of the office should be: 1. Violence and drugs; 2. Public corruption; 3. Financial crimes, and 4. Terrorism."

Lightfoot seems to have especially strong connections to city government, heading the Chicago police Office of Professional Standards between 2002 and 2005. Other candidates have also held administrative posts, including Fardon when he served as the No. 2 in the U.S. attorney's office in Nashville.

"What you see is that this seems to be a selection of people who are more administrators," said Zellner. "It is almost a retreat from a Pat Fitzgerald-type of prosecutor."

That, she added, didn't mean any one of the candidates wouldn't excel.

"You don't get nominated without having really good credentials," she said. "But it is difficult to know what philosophy someone will have until after a year or so. That transition will take time."

Federal investigations can take years before they result in indictments or go to trial, so any shift in direction under new leadership is likely to be incremental and happen over years.

A change in style is more likely, said Pissetzky.

As he racked up flashy convictions ? including of reputed mobsters and terrorists ? Fitzgerald gained a reputation as a no-nonsense prosecutor who erred on the side of secrecy and typically eschewed banter with reporters. He could be tenacious to a fault, defense attorneys said. Over the years, many complained that Fitzgerald pursued their clients with too much fervor, loading indictments up with as many charges as he could muster.

It's a style that his successor won't necessarily emulate.

Said Pissetzky, "I think they will try to make their own mark rather than trying to follow in his footsteps."

___

Follow Michael Tarm at www.twitter.com/mtarm.

Source: http://news.yahoo.com/chicagos-next-prosecutor-more-insider-180543335.html

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US hits borrowing limit, moves to avoid default

WASHINGTON (AP) ? The U.S. government is running up against its $16.4 trillion borrowing limit and is taking steps to avoid default.

Reaching the limit Monday sets up another dispute between the White House and Congress over taxes and spending in the new year.

Treasury Secretary Timothy Geithner says the government will take a series of accounting measures to avoid defaulting on its debt. On Monday, it suspended the issuance of new debt for two government retirement funds.

Last week, Geithner said the measures would save about $200 billion and avoid default for about two months.

Geithner said it is difficult to predict how long default can be avoided because of ongoing negotiations over tax and budget policies.

The debt limit is the amount the government can borrow to help finance its operations.

Source: http://news.yahoo.com/us-hits-borrowing-limit-moves-avoid-default-225039977--finance.html

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Le Parcel, Because Tampons And Monthly Subscription Services Go Hand In Hand

le parcel 1If ever there was a consumer product suited for monthly subscriptions, it would be tampons. It only takes one midnight trip to the pharmacy for you to agree with me. That's where Le Parcel comes in. It's a new startup that lets you choose which brand of feminine hygiene products you'd like to have shipped to you monthly, along with some chocolate of course.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/LarpxjpSAhY/

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Romo's 2 INT, TD, leave Cowboys, Skins 7-7 at half

LANDOVER, Md. (AP) ? With the NFC East title on the line, Tony Romo threw interceptions on each of Dallas' first two possessions before connecting with Jason Witten for a 9-yard touchdown pass Sunday night, and Washington rookie Alfred Morris ran for a 17-yard score, leaving the Cowboys and Redskins tied 7-7 at halftime.

It was a win-or-go-home game moved into prime time to mark the end of the NFL's regular season: Whichever team lost would miss the playoffs, and the winner would host the wild-card Seattle Seahawks in a first-round game next Sunday.

An eventful first half also included Redskins kicker Kai Forbath's first missed field-goal try in 18 career attempts.

After his early miscues, Romo got going on his third drive, a 13-play, 89-yard journey that lasted more than 7 1/2 minutes. It ended with Dallas barely beating an expiring play clock on third-and-goal from the 9, then Romo scrambling around in his trademark fashion before finding Witten in the end zone with about 8 minutes left in the second quarter.

Romo went 4 for 4 for 58 yards on the drive. Witten's first catch of the game, earlier in that possession, gave him 800 for his career, allowing him to join Tony Gonzalez (1,237) and Shannon Sharpe (815) as the only tight ends with at least that many.

Washington and rookie quarterback Robert Griffin III responded, going 68 yards in eight plays to tie it on Morris' run around the left side. Morris had 92 yards on 13 carries at halftime as he closed in on Clinton Portis' franchise rushing record for a season.

RG3, wearing a heavy black brace on his mildly sprained right knee, was 5 for 11 for 43 yards passing, and ran three times for 21 yards.

Romo was 10 for 16 for 119 yards in the first half. When he had an incompletion on third-and-9 from Washington's 34 in the last minute of the second quarter, Dallas opted to punt. The ball landed in the end zone for a touchback.

One key first-half injury: Cowboys receiver Miles Austin hurt his left ankle in the second quarter.

The Redskins won the opening coin toss, got the ball first and went three-and-out, with Dwayne Harris' 28-yard punt return setting up Dallas at the Washington 27. But on Dallas' third play on offense, Romo was intercepted by Redskins rookie Richard Crawford. Walking to the sideline, Romo gave intended receiver Kevin Ogletree a talking-to.

The Redskins then drove into field-goal range, before Forbath sent his 37-yard attempt off the right upright, ending his NFL-record streak of 17 consecutive makes to begin a career. Forbath made two field goals last week to surpass Saints kicker Garrett Hartley's old mark of 16 in a row.

Dallas' second drive also ended with Romo's pass getting picked off, this time by cornerback Josh Wilson at Washington's 13. The Redskins again did not capitalize, needing to punt the ball back.

The Cowboys were seeking the first division title and playoff berth since 2009. The Redskins, meanwhile, sought their first trip to the postseason since 2007 ? and first NFC East championship since 1999. Washington finished in last place each of the past four seasons.

Washington entered the day on a six-game winning streak and with a 9-6 record, while Dallas came in 8-7.

A victory over Dallas would make Washington the first club since the 1996 Jacksonville Jaguars to get to the playoffs after opening 3-6.

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Source: http://news.yahoo.com/romos-2-int-td-leave-cowboys-skins-7-025255678--spt.html

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Reid among 7 NFL coaches sacked in firing frenzy

Quite a day for NFL sacks.

Seven coaches and five general managers were fired Monday in a flurry of pink slips that were delivered the day after the regular-season ended.

There could be more, but so far the sent-packing scorecard looks like this:

Andy Reid in Philadelphia, Lovie Smith in Chicago, and Ken Whisenhunt in Arizona, all coaches who took teams to the Super Bowl, Norv Turner in San Diego, Pat Shurmur in Cleveland, Romeo Crennel in Kansas City and Chan Gailey in Buffalo.

Three teams made it a clean sweep, saying goodbye to the GM along with the coach ? San Diego, Cleveland, Arizona. General managers also were fired in Jacksonville and in New York, where Rex Ryan held onto his coaching job with the Jets despite a losing record.

Reid was the longest tenured of the coaches, removed after 14 seasons and a Super Bowl appearance in 2005 ? a loss to New England.

Smith spent nine seasons with the Bears, leading them to the 2007 Super Bowl ? a loss to the Indianapolis Colts.

Turner has now been fired as head coach by three teams. San Diego won the AFC West from 2006-09, but didn't make the postseason the last three years.

"Both Norv and A.J. are consummate NFL professionals, and they understand that in this league, the bottom-line is winning," Chargers President Dean Spanos said in a statement.

Whisenhunt was fired after six seasons, including taking the Cardinals to a Super Bowl loss to Pittsburgh after the 2008 season. He had more wins than any other coach in Cardinals history, going 45-51, and has one year worth about $5.5 million left on his contract. GM Rod Graves had been with Arizona for 16 years, nine in his current position. A 5-11 record after a 4-0 start cost him and Whisenhunt their jobs.

Gailey was dumped after three seasons with the Bills; Shurmur after two; and Crennel had one full season with the Chiefs.

Reid took over a 3-13 Eagles team in 1999, drafted Donovan McNabb with the No. 2 overall pick and quickly turned the franchise into a title contender.

He led them to a run of four straight NFC championship games, a streak that ended with a trip to the NFL title game. But the team hasn't won a playoff game since 2008 and after last season's 8-8 finish, owner Jeffrey Lurie said he was looking for improvement this year. Instead, it was even worse. The Eagles finished 4-12.

"When you have a season like that, it's embarrassing. It's personally crushing to me and it's terrible," Lurie said at a news conference. He said he respects Reid and plans to stay friends with him, "but, it is time for the Eagles to move in a new direction."

Shurmur went 9-23 in his two seasons with the Browns, who will embark on yet another offseason of change ? the only constant in more than a decade of futility. Cleveland has lost at least 11 games in each of the past five seasons and made the playoffs just once since returning to the NFL as an expansion team in 1999.

"Ultimately our objective is to put together an organization that will be the best at everything we do," Browns CEO Joe Banner said. " On the field, our only goal is trying to win championships."

Crennel took over with three games left in the 2011 season after GM Scott Pioli fired Todd Haley. Kansas City will have the No. 1 pick in the NFL draft as a result of having one of the worst seasons in its 53-year history. The only other time the Chiefs finished 2-14 was 2008, the year before Pioli was hired.

"I am embarrassed by the poor product we gave our fans this season, and I believe we have no choice but to move the franchise in a different direction," Chiefs chairman Clark Hunt said in a statement.

Gailey, the former Dallas Cowboys coach, compiled a 16-32 record in his three seasons in Buffalo, never doing better than 6-10.

"This will probably be, and I say probably, but I think it will be the first place that's ever fired me that I'll pull for," Gailey said.

Smith and the Bears went 10-6 this season and just missed a playoff spot. But Chicago started 7-1 and has struggled to put together a productive offense throughout Smith's tenure. His record was 81-63 with the Bears, and he took them to one Super Bowl loss and to one NFC championship game defeat.

Receiver and kick return standout Devin Hester was bitter about Smith's firing.

"The media, the false fans, you all got what you all wanted," Hester said as he cleared out his locker. "The majority of you all wanted him out. As players we wanted him in. I guess the fans ? the false fans ? outruled us. I thought he was a great coach, probably one of the best coaches I've ever been around."

The fired GMs included Mike Tannenbaum of the Jets; Gene Smith of the Jaguars; A.J. Smith of the Chargers and Tom Heckert of the Browns and Graves of Arizona.

"You hope that those guys that obviously were victims of black Monday land on their feet," Rams coach Jeff Fisher said. "You've got guys that have been to Super Bowls and won championship games and all of a sudden they've forgot how to coach, I guess."

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Source: http://news.yahoo.com/reid-among-7-nfl-coaches-sacked-firing-frenzy-221335326--nfl.html

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Psychiatric exam for suspect in NYC subway death

NEW YORK (AP) ? A woman accused of pushing a man to his death in front of a subway train told police she did so because she blamed Muslims for the Sept. 11 attacks, and because "I thought it would be cool," prosecutors said at a court hearing.

Erika Menendez was charged Saturday night with murder as a hate crime after she told police she spontaneously pushed Sunando Sen.

She laughed so hard during her arraignment in Queens criminal court that Judge Gia Morris told her lawyer: "You're going to have to have your client stop laughing."

Defense attorney Dietrich Epperson said Menendez's behavior in court was no different from how she had been acting when he spoke to her privately, and said his client didn't really think the proceedings were funny. He represented her for the arraignment only and had no further comment.

Menendez was held without bail and ordered to have a mental health exam. Her next court appearance is scheduled for Jan. 14.

Prosecutors said Menendez pushed Sen, a 46-year-old native of India, to his death Thursday night because she blamed "Muslims, Hindus and Egyptians" for the Sept. 11 terrorist attacks.

"I pushed a Muslim off the train tracks because I hate Hindus and Muslims ? ever since 2001 when they put down the twin towers I've been beating them up," Menendez told police, according to the Queens district attorney's office.

Friends and co-workers said Sen, a native of Calcutta, was Hindu. He had lived in Queens for decades and was a graphic designer and copy shop owner. Sen was standing on an elevated platform of the 7 train that travels between Manhattan and Queens when he was shoved from behind as the train entered the station.

Witnesses told police a woman had been mumbling to herself and was sitting on a bench behind Sen until the train pulled in, then shoved him from behind. She then fled.

Police released a sketch and surveillance footage of a woman running from the subway station. Menendez was arrested after a passer-by saw her on the street and thought she looked like the wanted suspect. Witnesses identified her in a lineup and she was questioned by police, when she implicated herself, according to police and prosecutors.

Angel Luis Santiago, who used to work at the Queens building where Menendez's mother and stepfather live, said he was shocked by her arrest.

"It surprised me what she did," he said. "She never acted that way."

According to the district attorney's office, Menendez said, "There is no reason. I just pushed him in front of the train because I thought it would be cool."

Sen was the second man to die after being pushed in front of a New York City subway train this month. Ki-Suck Han was killed in a midtown Manhattan subway station on Dec. 3. A homeless man was arrested and charged with murder in that case and is awaiting trial. He claimed he acted in self-defense.

Such subway deaths are rare, but transit officials said last week they would consider installing barriers with sliding doors on some subway platforms. Other cities including Paris and London have installed such barriers.

___

Associated Press Writer Karen Matthews contributed to this report.

Source: http://news.yahoo.com/psychiatric-exam-suspect-nyc-subway-death-074634459.html

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